The national Ministry of Science and Technology (MOST) and the Science and Technology Council of the Macao SAR Government (CCT) signed the Agreement on the Establishment of the Mainland and Macao Science and Technology Cooperation Committee in October 2005 to, through setting up the committee and holding regular meetings, organize and coordinate the exchange and cooperation in science and technology and related sectors between the relevant departments of the two places, thereby promoting the development of the relevant fields in the two sides. The Macao-side liaison office of the said committee has been transferred to the DSEDT after the latter being reorganized and vested with the new function of promoting technology and innovation development in 2021.

The meetings of the committee are held every year alternately in Macao and the Mainland since the first meeting in 2007. The most recent one is the 17th meeting held in Macao in October 2023. It was attended by representatives from, among others, the MOST; the Liaison Office of the Central People’s Government in the Macao Special Administrative Region; the Chinese Academy of Sciences; the National Natural Science Foundation of China; the China Association for Science and Technology; the Department of Science and Technology of Guangdong Province; the Zhuhai Municipal People’s Government and the Zhuhai Science and Technology Innovation Bureau; the Economic Development Bureau of Guangdong-Macao Intensive Cooperation Zone in Hengqin; and, from Macao, the Office of the Secretariat for Economy and Finance; the DSEDT; the Science and Technology Development Fund; the Education and Youth Development Bureau; the Marine and Water Bureau; the Environmental Protection Bureau; the Macao Post and Telecommunications Bureau; the Pharmaceutical Administration Bureau; the Macau Productivity and Technology Transfer Center; the University of Macau; the Macao Polytechnic University; and the Macau University of Science and Technology, among others.